The Asia-Pacific Journal of Ophthalmology

Asia-Pacific Journal of Ophthalmology:

Issue 4, July/August 2018 Review Article

Neuromyelitis Optica: Review and Utility of Testing Aquaporin-4 Antibody in Typical Optic Neuritis

Seay, Meagan; Rucker, Janet C.



Author Information


From the Departments of *Neurology and †Ophthalmology, New York University School of Medicine, New York, New York.


Reprints: Janet C. Rucker, MD, Bernard A. and Charlotte Marden Professor of Neurology and Ophthalmology, New York University School of Medicine, 222 E. 41st St. 14th Floor, New York, New York, 10017. E-mail: Janet.Rucker@nyumc.org.



Abstract


Neuromyelitis optica (NMO) is an autoimmune, inflammatory demyelinating disorder often leading to severe vision impairment and disability. The discovery of a diagnostic biomarker, the aquaporin-4 antibody (AQP4-IgG), transformed the clinical diagnosis and treatment of NMO and broadened the spectrum of disease [NMO spectrum disorders (NMOSD)]. Though the antibody is highly sensitive and specific to NMOSD, routine testing in patients with typical optic neuritis is considered controversial. This article will provide a brief review of NMOSD and highlight the pros and cons of routine testing in typical optic neuritis.




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