The Asia-Pacific Journal of Ophthalmology

Asia-Pacific Journal of Ophthalmology:

Issue 4, July/August 2016 Review Article

Exercise as Gene Therapy: BDNF and DNA Damage Repair

Schmidt, Robin H.; Nickerson, John M.; Boatright, Jeffrey H.



Author Information


From the *Department of Ophthalmology, Emory University School of Medicine, Atlanta; and †Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA.


Reprints: Jeffrey H. Boatright, PhD, Room B5511, Emory Eye Center 1365B Clifton Rd, NE Atlanta, GA, 30322. E-mail: jboatri@emory.edu.



Abstract


DNA damage is a common feature of neurodegenerative illnesses, and the ability to repair DNA strand breaks and lesions is crucial for neuronal survival, reported by Jeppesen et al (Prog Neurobiol2011;94:166–200) and Shiwaku et al (Curr Mol Med. 2015;15:119–128). Interventions aimed at repairing these lesions, therefore, could be useful for preventing or delaying the progression of disease. One potential strategy for promoting DNA damage repair (DDR) is exercise. Although the role of exercise in DDR is not understood, there is increasing evidence that simple physical activity may impact clinical outcomes for neurodegeneration. Here, we discuss what is currently known about the molecular mechanisms of brain-derived neurotrophic factor and how these mechanisms might influence the DDR process.




Full Text

View PDF Online

Download PDF

APJO Express
2019
2018
2017
E-Newsletter+
2019
2018
2017
2016

More About APAO

  • http://www.apaophth.org/
  • http://2019.apaophth.org/
  • http://www.apaophth.org/apao-ldp/
  • http://www.apaophth.org/fellowship-program/
  • 1
  • 2
  • 3
  • 4
< >
All Rights Reserved © Asia-Pacific Academy of Ophthalmology  
Title×
Confirm
Cancel